Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
Identifieur interne : 000010 ( an2020/Analysis ); précédent : 000009; suivant : 000011Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
Auteurs : Youn-Sang Jung [États-Unis] ; Jae-Il Park [États-Unis]Source :
- Experimental & Molecular Medicine [ 1226-3613 ] ; 2020.
Abstract
Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless, the blockade of Wnt signaling causes side effects such as impairment of tissue homeostasis and regeneration. Recently, several studies have identified cancer-specific Wnt signaling regulators. In this review, we discuss the Wnt inhibitors currently being used in clinical trials and suggest how additional cancer-specific regulators could be utilized to treat Wnt signaling-associated cancer.
Url:
DOI: 10.1038/s12276-020-0380-6
PubMed: 32037398
PubMed Central: 7062731
Affiliations:
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In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless, the blockade of Wnt signaling causes side effects such as impairment of tissue homeostasis and regeneration. Recently, several studies have identified cancer-specific Wnt signaling regulators. 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sortKey="Suarez Almazor, Me" uniqKey="Suarez Almazor M">ME Suarez-Almazor</name></author><author><name sortKey="Russell, As" uniqKey="Russell A">AS Russell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bowman, Ej" uniqKey="Bowman E">EJ Bowman</name></author><author><name sortKey="Graham, La" uniqKey="Graham L">LA Graham</name></author><author><name sortKey="Stevens, Th" uniqKey="Stevens T">TH Stevens</name></author><author><name sortKey="Bowman, Bj" uniqKey="Bowman B">BJ Bowman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huss, M" uniqKey="Huss M">M Huss</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Jung, Youn Sang" sort="Jung, Youn Sang" uniqKey="Jung Y" first="Youn-Sang" last="Jung">Youn-Sang Jung</name></region><name sortKey="Park, Jae Il" sort="Park, Jae Il" uniqKey="Park J" first="Jae-Il" last="Park">Jae-Il Park</name><name sortKey="Park, Jae Il" sort="Park, Jae Il" uniqKey="Park J" first="Jae-Il" last="Park">Jae-Il Park</name><name sortKey="Park, Jae Il" sort="Park, Jae Il" uniqKey="Park J" first="Jae-Il" last="Park">Jae-Il Park</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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